Unwinding the Role of FACT in Cas9-based Genome Editing.

TitleUnwinding the Role of FACT in Cas9-based Genome Editing.
Publication TypeJournal Article
Year of Publication2020
AuthorsBD Cosgrove, and CA Gersbach
JournalMolecular Cell
Volume79
Start Page365
Issue3
Pagination365 - 367
Date Published08/2020
Abstract

In a recent issue of Molecular Cell, Wang et al. (2020) employ unbiased proteomics approaches and live-cell imaging to reveal a key role for the histone chaperone complex FACT (SPT16 and SSRP1) in governing Cas9 turnover at the DNA target site during genome and epigenome editing.

DOI10.1016/j.molcel.2020.07.016
Short TitleMolecular Cell