Publications

  1. TM Gibson, CA Gersbach. The role of single-cell analyses in understanding cell lineage commitment. Biotechnology Journal (ePub March 21, 2013).
  2. P Perez-Pinera, DG Ousterout, JM Brunger, AM Farin, KA Glass, F Guilak, GE Crawford, AJ Hartemink, CA Gersbach. Synergistic and Tunable Human Gene Activation by Combinations of Engineered Transcription Factors. Nature Methods 10(3):239-42 (2013).
  3. Tremblay et al., Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases. Molecular Therapy 21(2):266-8 (2013).
  4. MS Bhakta, IM Henry, DG Ousterout, KT Das, SH Lockwood, JF Meckler, MC Wallen, A Zykovich, Y Yu, H Leo, L Xu, CA Gersbach, DJ Segal.  Highly Active Zinc Finger Nucleases by Extended Modular Assembly. Genome Research 23(3):530-8 (2013).
  5. LR Polstein, CA Gersbach.  Light-Inducible Spatiotemporal Control of Gene Activation by Customizable Zinc Finger Transcription Factors.  J. Am. Chem. Soc. 134(40):16480-3 (2012).
  6. P Perez-Pinera, DG Ousterout, CA Gersbach. Advances in Targeted Genome Editing. Current Opinion in Chemical Biology 16(3):268-277 (2012).
    -Highlighted by F1000 Biology
  7. P Perez-Pinera, DG Ousterout, MT Brown, CA Gersbach. Gene Targeting to the ROSA26 Locus Directed by Engineered Zinc Finger Nucleases. Nucleic Acids Res 40(8):3741-52 (2012).
  8. CA Gersbach, T Gaj, RM Gordley, AM Mercer, CF Barbas, III. Targeted Plasmid Integration into the Human Genome by an Engineered Zinc Finger Recombinase. Nucleic Acids Res 39(17):7868-7878 (2011).
  9. T Gaj, AC Mercer, CA Gersbach, RM Gordley,  CF Barbas, III.  Structure-Guided Reprogramming of Serine Recombinase Specificity.  Proc. Natl. Acad. Sci. USA 108(2):498-503 (2011).
    -Highlighted in Nature Biotechnology 29(2):140 (2011).
  10. CA Gersbach, T Gaj, RM Gordley, CF Barbas, III. Directed Evolution of Recombinase Specificity by Split Gene Reassembly. Nucleic Acids Res 38(12):4198-4206 (2010).
    -Highlighted as a Featured Article by the Editors of Nucleic Acids Research.
  11. RM Gordley, CA Gersbach, CF Barbas, III.  Synthesis of Programmable Integrases.  Proc. Natl. Acad. Sci. USA 106(13):5053-8 (2009).
    -Highlighted in ACS Chemical Biology 4(5):319 (2009).
    -Highlighted in New Scientist 2726:13 (2009).
  12. CA Gersbach, SR Coyer, JM Le Doux, AJ Garcia.  Biomaterial-Mediated Retroviral Gene Delivery Using Self-Assembled Monolayers. Biomaterials 28(34):5121-7 (2007).
  13. S Pregizer, A Barski, CA Gersbach, AJ Garcia, B Frenkel.  Identification of Novel Runx2 Targets in Osteoblasts: Cell Type-Specific, BMP-Dependent Regulation of Tram2.  J. Cell. Biochem. 102(6):1458-71 (2007).
  14. CA Gersbach, JE Phillips, AJ Garcia. Genetic Engineering for Skeletal Regenerative Medicine.  Annu. Rev. Biomed. Eng. 15(9):87-119 (2007).
  15. CA Gersbach, RE Guldberg, AJ Garcia. In Vitro and In Vivo Osteoblastic Differentiation of BMP-2- and Runx2-Engineered Skeletal Myoblasts. J. Cell. Biochem. 100(5):1324-36 (2007).
  16. JE Phillips, CA Gersbach, AJ Garcia. Virus-Based Gene Therapy Strategies for Bone Regeneration. Biomaterials 28(2):211-229 (2007).
  17. CA Gersbach, JM Le Doux, RE Gulderg, AJ Garcia. Inducible Regulation of Runx2-Stimulated Osteogenesis.  Gene Ther. 13(11):873-82 (2006).
  18. JE Phillips, CA Gersbach, AM Wojtowicz, AJ Garcia. Glucocorticoid-Induced Osteogenesis is Negatively Regulated by Runx2/Cbfa1 Serine Phosphorylation.  J. Cell Sci. 119(3):581-91 (2006).
  19. MA Lan, CA Gersbach, KE Michael, BG Keselowsky, AJ Garcia. Myoblast Proliferation and Differentiation on Fibronectin-Coated Self-Assembled Monolayers Presenting Different Surface Chemistries. Biomaterials 26(22):4523-31 (2005).
  20. CA Gersbach, BA Byers, GK Pavlath, RE Guldberg, AJ Garcia. Runx2/Cbfa1-Genetically Engineered Skeletal Myoblasts Mineralize Collagen Scaffolds In Vitro.  Biotechnol. Bioeng. 88(3):369-378 (2004).
  21. CA Gersbach, BA Byers, GK Pavlath, AJ Garcia. Runx2/Cbfa1 Stimulates Transdifferentiation of Primary Skeletal Myoblasts into a Mineralizing Osteoblastic Phenotype. Exp. Cell Res. 300(2):406-417 (2004).
  22. AJ Garcia, RE Guldberg, BA Byers, CA Gersbach, JE Phillips. Addressing cell-sourcing limitations with gene therapy. IEEE Eng. Med. Biol. Mag. 22(5):65-70 (2003).