News

CRISPR 50-fold

April 16, 2019 | Duke Engineering News

Engineering "Hairpins" Increases CRISPR Accuracy

Added piece of RNA could improve the precision of CRISPR 50-fold

muscles of similar mice one year after gene-editing treatment (right). Dystrophin production (green) is restored in treated animals, despite therapy-related immune response to the Cas9 editing enzyme (dark spots in white inset).

February 26, 2019 | NIH Director's Blog

More Progress Toward Gene Editing for Kids with Muscular Dystrophy

The Gersbach lab's latest work on gene editing for Duchenne Muscular Dystrophy was highlighted in the NIH Director's Blog.

DNA

February 18, 2019 | Duke Engineering News

Single Genetic Editing Treatment Provides Long-Term Benefits in Mice

Genetic edits and protein restoration in mouse models of Duchenne muscular dystrophy remain viable one year after single CRISPR treatment

epigenomes

January 1, 2019 | The Scientist

Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease

Using CRISPR and other tools, the Gersbach lab and other researchers are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.

November 18, 2018 | Duke Today

Three Duke Seniors Named Rhodes Scholars

Undergraduate Researcher in the Gersbach lab, Ariel Kantor, is one of three Duke seniors to earn a Rhodes Scholarship.

Tim Reddy, Kris Wood, Greg Crawford and Charlie Gersbach

October 19, 2018 | Duke Medicine

From Innovation to Impact

Duke researchers are taking their discoveries from the research lab into the marketplace

epigenomes

September 26, 2018 | Duke Today

Exploring the Mechanics of Gene Expression

New NSF grant links four Duke engineers to explore how mechanical changes to genetic material affects gene expression, cancer development.

Histological sections of liver from control mice treated with saline (left) and the CRISPR/Cas9 epigenetic repression system in which cholesterol levels were lowered (right) show generally normal and healthy tissue.

April 27, 2018 | Duke Today

CRISPR/Cas9 Silences Gene Associated with High Cholesterol

Biomedical engineers at Duke University have used a CRISPR/Cas9 genetic engineering technique to turn off a gene that regulates cholesterol levels in adult mice, leading to reduced blood cholesterol levels and gene repression lasting for six months after a single treatment.