Welcome to The Gersbach Lab at Duke University

Molecular and Cellular Engineering Applied to Regenerative Medicine and Gene Therapy

The Gersbach Lab is focused on engineering new methods for directing cell behavior to regenerate diseased or damaged tissues and treat genetic diseases.  We are particularly interested in developing and applying technologies that manipulate cellular processes at the genetic level.  Our work capitalizes on the products of the Genomic Revolution and modern advances in the fields of genome and epigenome editing, genetic reprogramming, gene delivery, protein engineering, stem cell transplantation, and synthetic  biology to create innovative biologic approaches to improving human health.  These studies also facilitate a better understanding of complex processes including organogenesis, cell lineage determination, and gene regulation that will ultimately lead to improved design of drugs and biotherapeutics.  Our efforts are catalyzed by interdisciplinary collaborations with investigators in engineering and medicine at Duke and other institutions.








Current News

January 15, 2016 – Chris’s paper is highlighted in Nature and NIH Research Matters.

December 31, 2015 – Chris’s paper is highlighted in the New York TimesScience MagazineThe GuardianBBCStat NewsGEN News, and Rare Disease Report.

December 31, 2015 – Chris’s paper on in vivo gene editing with CRISPR for Duchenne muscular dystrophy is published in Science.

December 23, 2015 - Charlie is co-Guest Editor with Prof. Jennifer Doudna for a special issue of Genome Biology on genome editing. Read our editorial here.

December 3, 2015 - Epigenome editing work from the Gersbach Lab is highlighted in Nature.

October 26, 2015 - Pratiksha's paper on CRISPR/Cas9-based repressors of gene regulatory elements is published in Nature Methods.

October 1, 2015 - Isaac's review on genome engineering and functional genomics is published in the 20th anniversary issue of Genome Research.

September 17, 2015 - Our collaborative work with the Marszalek lab on specificity of CRISPR is published in Nucleic Acids Research

August 31, 2015 - Liad is awarded the Robert Plonsey Fellowship in Biomedical Engineering - Congrats Liad!

August 1, 2015 - Tyler Klann is awarded an NIH Predoctoral Fellowship from the Duke Center for Biomolecular and Tissue Engineering. Congrats Tyler!

More News