Welcome to The Gersbach Lab at Duke University

Molecular and Cellular Engineering Applied to Regenerative Medicine and Gene Therapy

The Gersbach Lab is focused on engineering new methods for directing cell behavior to regenerate diseased or damaged tissues and treat genetic diseases.  We are particularly interested in developing and applying technologies that manipulate cellular processes at the genetic level.  Our work capitalizes on the products of the Genomic Revolution and modern advances in the fields of genetic reprogramming, gene delivery, protein engineering, stem cell transplantation, and synthetic  biology to create innovative biologic approaches to improving human health.  These studies also facilitate a better understanding of complex processes including organogenesis, cell lineage determination, and gene regulation that will ultimately lead to i mproved design of drugs and biotherapeutics.  Our efforts are catalyzed by interdisciplinary collaborations with investigators in engineering and medicine at Duke and other institutions.







Current News

March 7, 2015  - Lauren's paper on light-inducible CRISPR-based gene regulation is highlighted in Biotechniques.

February 27, 2015  - The Muscular Dystrophy Association releases statements on our work using CRISPR/Cas9 technology for gene therapy for Duchenne muscular dystrophy here and here.

February 18, 2015  - Dave' paper on correction of mutations that cause Duchenne muscular dystrophy with the CRISPR/Cas9 system is published in Nature Communications.  Read the associated press releases from the Duke School of Engineering and FierceBiotech.

February 9, 2015  - Lauren's paper on light-inducible CRISPR/Cas9-based gene regulation is published in Nature Chemical Biology.  Read Pratt's release here.

January 12, 2015  - We welcome Matt Gemberling, Ph.D. to the Gersbach Lab as a postdoctoral fellow.

January 7, 2015  - Aishu Ramamurthi and Sarina Madhavan join the lab as undergraduate research assistants.

January 5, 2015  - The Gersbach Lab is part of a Duke team led by Prof. Tim Reddy to be awarded an NIH grant to decipher the Genomics of Gene Regulation.

December 17, 2014  -  Pratiksha’s paper, in collaboration with the Guilak lab, on enhancing cartilage formation by induced pluripotent stem cells by manipulating cell cycle inhibitors is published in Tissue Engineering.

December 12, 2014  -  The Gersbach and Asokan Labs receive a Duke-UNC Clinical and Translational Science Award (CTSA) Consortium Collaborative Translational Research Grant to collaborate on developing in vivo genome editing technologies.

December 10, 2014  -  Ami’s paper on protein engineering of transcription factors to enhance genetic reprogramming is published in ACS Synthetic Biology.

December 10, 2014  -  Dave’s paper on gene editing with zinc finger nucleases for Duchenne Muscular Dystrophy is published in Molecular Therapy.

December 1, 2014 – Duke University licenses technology developed in the Gersbach Lab to Editas Medicine, a startup company focused on therapeutic genome engineering. Read the release from Editas, Duke, and others.

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