The Gersbach Lab is dedicated to applying innovative methods in molecular and genetic engineering to regenerative medicine, treating genetic disease, and enhancing our understanding of fundamental biological processes. In particular, our research aims to develop new technologies to modify genome sequences, epigenomic regulation, and cellular gene networks in a precise and targeted manner. These new technologies are then applied to correction of genetic diseases, directing cell differentiation, tissue regeneration, drug target discovery, or answering fundamental biological questions regarding gene regulation and genome structure and function. Examples of technologies used in our research include genome and epigenome editing with CRISPR/Cas9 and other DNA-targeting systems, protein engineering, directed evolution, genetic reprogramming, and optogenetics.
Welcome to the Gersbach Lab!
- Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.
- Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes.
- Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy.
- Pulling the genome in opposite directions to dissect gene networks