Welcome to The Gersbach Lab at Duke University

Molecular and Cellular Engineering Applied to Regenerative Medicine and Gene Therapy

The Gersbach Lab is focused on engineering new methods for directing cell behavior to regenerate diseased or damaged tissues and treat genetic diseases.  We are particularly interested in developing and applying technologies that manipulate cellular processes at the genetic level.  Our work capitalizes on the products of the Genomic Revolution and modern advances in the fields of genetic reprogramming, gene delivery, protein engineering, stem cell transplantation, and synthetic  biology to create innovative biologic approaches to improving human health.  These studies also facilitate a better understanding of complex processes including organogenesis, cell lineage determination, and gene regulation that will ultimately lead to i mproved design of drugs and biotherapeutics.  Our efforts are catalyzed by interdisciplinary collaborations with investigators in engineering and medicine at Duke and other institutions.







Current News

October 26, 2015 - Pratiksha's paper on CRISPR/Cas9-based repressors of gene regulatory elements is published in Nature Methods.

October 1, 2015 - Isaac's review on genome engineering and functional genomics is published in the 20th anniversary issue of Genome Research.

September 17, 2015 - Our collaborative work with the Marszalek lab on specificity of CRISPR is published in Nucleic Acids Research

August 31, 2015  - Liad is awarded the Robert Plonsey Fellowship in Biomedical Engineering - Congrats Liad!

August 1, 2015 - Tyler Klann is awarded an NIH Predoctoral Fellowship from the Duke Center for Biomolecular and Tissue Engineering. Congrats Tyler!

July 30, 2015   Tyler Gibson successfully defends his thesis - congrats Dr. Gibson!

July 1, 2015 - Chris is awarded a Hartwell Foundation Postdoctoral Fellowship  - congrats Chris!

May 29, 2015 - Ami is awarded the Duke University Department of Biomedical Engineering Award for Excellence in Mentoring. Congrats Ami and thank you for your mentorship!

May 29, 2015 - Pratiksha wins the best poster award at the Duke Biomedical Engineering Retreat!

May 29, 2015 - Lauren's paper on specificity of engineered transcriptional activators is published in Genome Research.

May 19, 2015 - Read here about our collaborative work with the Reddy, Crawford, Hartemink, and Englehardt labs on studyging gene regulation in response to glucocorticoids.

May 15, 2015 - Chris is awarded The Hartwell Foundation Postdoctoral Fellowship. Congrats Chris!

May 13, 2015 - Ami, Pratiksha, Lauren, Chris, Josh, and Jonathan all recieve travel awards to present their work at the Annual Meeting of the American Society for Gene and Cell Therapy. Congrats to Lauren for also receiving an Excellence in Research Award and Ami for receiving a Best Poster award.

May 8, 2015 - Tyler's paper on single molecule analysis of muscle cell differentiation is published in Integrative Biology.

April 25, 2015 - Ami, Pratiksha, Lauren, Chris, Isaac, Josh, and Jonathan present their work at the 2nd International Mammalian Synthetic Biology Workshop.

April 20, 2015 - Duke Translational Medicine Institute highlights our collaboration with the Asokan Lab to generate new gene therapies.

April 9 - Lauren recieves the Student Achievement Award from the Duke Center for Biomolecular and Tissue Engineering.

April 9 - Isaac recieves the Postdoctoral Achievement Award from the Duke Center for Biomolecular and Tissue Engineering.

April 7, 2015 - Isaac's paper is highlighted in Nature, Nature BiotechnologyNature MethodsThe ScientistGenetic Engineering and Biotechnology NewsNature Reviews Molecular Cell BiologyMolecular Therapy, and Duke.

April 6, 2015 - Isaac's paper on epigenome editing with a CRISPR/Cas9-based acetyltransferase is published in Nature Biotechnology.

April 6, 2015 - Our collaborative work with the Crawford and West labs in studying chromatin accessbility of neuronal enhancers is published in Nature Neuroscience.

March 23, 2015 - Lauren successfully defends her thesis - Congratulations Dr. Polstein Toth!

March 23, 2015 - Feimei is accepted into the Summer Scholar program through the Duke Center for Genomic and Computational Biology. Congrats Feimei! 

March 10, 2015 - Dave's paper is highlighted by Nature Reviews Neurology.

March 10, 2015 - Ami successfully defends her thesis - Congratulations Dr. Kabadi!

March 7, 2015  - Lauren's paper on light-inducible CRISPR-based gene regulation is highlighted in Biotechniques.

February 27, 2015  - The Muscular Dystrophy Association releases statements on our work using CRISPR/Cas9 technology for gene therapy for Duchenne muscular dystrophy here and here.

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