The Gersbach Lab is dedicated to applying innovative methods in molecular and genetic engineering to regenerative medicine, treating genetic disease, and enhancing our understanding of fundamental biological processes. In particular, our research aims to develop new technologies to modify genome sequences, epigenomic regulation, and cellular gene networks in a precise and targeted manner. These new technologies are then applied to correction of genetic diseases, directing cell differentiation, tissue regeneration, drug target discovery, or answering fundamental biological questions regarding gene regulation and genome structure and function. Examples of technologies used in our research include genome and epigenome editing with CRISPR/Cas9 and other DNA-targeting systems, protein engineering, directed evolution, genetic reprogramming, and optogenetics.
Welcome to the Gersbach Lab!
- Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.
- Mammalian Synthetic Biology: Engineering Biological Systems
- Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.
- CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments.