Welcome to The Gersbach Lab at Duke University

Molecular and Cellular Engineering Applied to Regenerative Medicine and Gene Therapy

The Gersbach Lab is focused on engineering new methods for directing cell behavior to regenerate diseased or damaged tissues and treat genetic diseases.  We are particularly interested in developing and applying technologies that manipulate cellular processes at the genetic level.  Our work capitalizes on the products of the Genomic Revolution and modern advances in the fields of genetic reprogramming, gene delivery, protein engineering, stem cell transplantation, and synthetic  biology to create innovative biologic approaches to improving human health.  These studies also facilitate a better understanding of complex processes including organogenesis, cell lineage determination, and gene regulation that will ultimately lead to i mproved design of drugs and biotherapeutics.  Our efforts are catalyzed by interdisciplinary collaborations with investigators in engineering and medicine at Duke and other institutions.







Current News

June 27, 2014 - Pratiksha, Lauren, Ami, and Dave all present at the FASEB Science Research Conference on Genome Engineering. Congrats to Pratkisha, Lauren, and Dave for winning student travel awards!

June 26, 2014 -We receive funding from the Duke-Coulter Translational Partnership Program to advance our work on genome editing for Duchenne muscular dystrophy.

June 2, 2014   - Chris Nelson joins the lab as a postdoctoral fellow. Welcome Chris!

June 2, 2014 - Feimei Liu and Hunter Hutchinson join the lab as undergraduate research fellows through the Howard Hughes Undergraduate Program and the IGSP Summer Fellowship Program.

May 30, 2014   - Charlie co-authors a review on the engineered zinc finger protein technology in Accounts of Chemical Research.

May 21, 2014   - Dave, Dewran, Tyler, Ami, Pratiksha, Josh, Jonathan, and Charlie all present at the 17th Annual Meeting of the American Society of Gene and Cell Therapy. Congrats to Dave and Dewran for winning Meritorious Abstract Travel Awards!

May 10, 2014   - Dr. Ousterout graduates!

May 7, 2014   - Charlie co-authors a column in Nature Medicine on recent advances in using the CRISPR technology for gene therapy.

April 22, 2014   - Katie's paper on gene therapy for immunomodulation in cartilage tissue engineering is published in Biomaterials. 

April 13, 2014   - Lauren's chapter on light-inducible zinc finger proteins is published in Methods in Molecular Biology. 

April 4, 2014   - Dave successfully defends his PhD thesis.  Congrats Dr. Ousterout!

April 1, 2014   - The Guilak and Gersbach labs receive an R21 grant from the National Institutes of Health to study the role of genetic variation in osteoarthritis.

March 20, 2014   - Dave receives the Student Achievement Award from the Duke Center for Biomolecular and Tissue Engineering.  Congrats Dave!

March 4, 2014 - Charlie is quoted in a New York Times article on genome editing with CRISPR.

March 3, 2014 - Jonathan's paper is highlighted by both the NIH and Wired.

March 1, 2014 - Charlie co-authors an article on Genome Editing Technologies in Genetic Engineering News.

February 18, 2014 - Jonathan's collaborative work between the Guilak and Gersbach labs on gene therapy for cartilage tissue enginering is published in PNAS.  Read Pratt's press release here.


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