Welcome to The Gersbach Lab at Duke University

Molecular and Cellular Engineering Applied to Regenerative Medicine and Gene Therapy

The Gersbach Lab is focused on engineering new methods for directing cell behavior to regenerate diseased or damaged tissues and treat genetic diseases.  We are particularly interested in developing and applying technologies that manipulate cellular processes at the genetic level.  Our work capitalizes on the products of the Genomic Revolution and modern advances in the fields of genetic reprogramming, gene delivery, protein engineering, stem cell transplantation, and synthetic  biology to create innovative biologic approaches to improving human health.  These studies also facilitate a better understanding of complex processes including organogenesis, cell lineage determination, and gene regulation that will ultimately lead to i mproved design of drugs and biotherapeutics.  Our efforts are catalyzed by interdisciplinary collaborations with investigators in engineering and medicine at Duke and other institutions.







Current News

September 1, 2014   - Josh Black is awarded an NIH Predoctoral Fellowship from the Duke Center for Biomolecular and Tissue Engineering.

August 15, 2014   - Tyler Klann and Liad Holtzman join the lab as PhD students in the Duke Biomedical Engineering Department.

August 13, 2014   - Ami and Dave's paper on a lentiviral system for multiplex genome engineering with CRISPR/Cas9 is published in Nucleic Acids Research.

July 8, 2014   - Ami's review on engineered TALE- and CRISPR/Cas9-based transcription factors is published in Methods.

June 27, 2014 - Pratiksha, Lauren, Ami, and Dave all present at the FASEB Science Research Conference on Genome Engineering. Congrats to Pratkisha, Lauren, and Dave for winning student travel awards!

June 26, 2014 - We receive funding from the Duke-Coulter Translational Partnership Program to advance our work on genome editing for Duchenne muscular dystrophy.

June 11, 2014   - Pablo and Charlie publish an editorial on using engineered transcription factors for gene therapy and regenerative medicine in Expert Opinion on Therapeutic Targets

June 2, 2014   - Chris Nelson joins the lab as a postdoctoral fellow. Welcome Chris!

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