Welcome to The Gersbach Lab at Duke University

Molecular and Cellular Engineering Applied to Regenerative Medicine and Gene Therapy

The Gersbach Lab is focused on engineering new methods for directing cell behavior to regenerate diseased or damaged tissues and treat genetic diseases.  We are particularly interested in developing and applying technologies that manipulate cellular processes at the genetic level.  Our work capitalizes on the products of the Genomic Revolution and modern advances in the fields of genetic reprogramming, gene delivery, protein engineering, stem cell transplantation, and synthetic  biology to create innovative biologic approaches to improving human health.  These studies also facilitate a better understanding of complex processes including organogenesis, cell lineage determination, and gene regulation that will ultimately lead to i mproved design of drugs and biotherapeutics.  Our efforts are catalyzed by interdisciplinary collaborations with investigators in engineering and medicine at Duke and other institutions.







Current News

April 4, 2014   - Dave successfully defends his PhD thesis.  Congrats Dr. Ousterout!

April 1, 2014   - The Guilak and Gersbach labs receive an R21 grant from the National Institutes of Health to study the role of genetic variation in osteoarthritis.

March 20, 2014   - Dave receives the Student Achievement Award from the Duke Center for Biomolecular and Tissue Engineering.  Congrats Dave!

March 4, 2014 - Charlie is quoted in a New York Times article on genome editing with CRISPR.

March 3, 2014 - Jonathan's paper is highlighted by both the NIH and Wired.

March 1, 2014 - Charlie co-authors an article on Genome Editing Technologies in Genetic Engineering News.

February 18, 2014 - Jonathan's collaborative work between the Guilak and Gersbach labs on gene therapy for cartilage tissue enginering is published in PNAS.  Read Pratt's press release here.

January 31, 2014 -Cameron is going to be on Jeopardy!

January 28, 2014 -Our work with CRISPR is highlighted in New Scientist.

January 15, 2014 - Charlie recieves the 2014 Outstanding New Investigator Award from the American Society for Gene and Cell Therapy.

 January 9, 2014  - Our work on genome editing for correcting muscular dystrophy is highlighted by the MDA.

December 12, 2013 - Charlie co-authors an article in Forbes.com with Tom Katsouleas, Dean of Engineeering, on the value of the iGEM competition on undergraduate engineering education.

November 22, 2013 - Dewran successfully defends his Masters thesis.  Congrats Dewran!

November 1, 2013 - We are excited to have Dr. Isaac Hilton join the lab as a postdoctoral fellow.

October 1, 2013 - Ami, Katie, and Suyash are featured in GenomeLife for their work, and the Gersbach Lab is highlighted for bridging the Pratt School of Engineering and the Institute for Genome Sciences and Policy.

September 15, 2013 - The Gersbach Lab receives an NIH R01 grant to develop tools to precisely manipulate the human epigenome with Duke IGSP collaborators Greg Crawford and Tim Reddy.

September 1, 2013 - In collaboration with the Guilak lab, we have received funding from the Nancy Taylor Foundation to develop stem cell therapies for chronic diseases.

August 23, 2013 - Our work on CRISPR-mediated gene regulation is highlighted in a news story in Science.

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