• Gersbach Lab, Fall 2018

    The Gersbach Lab is a diverse and dynamic group of scientists and engineers developing technologies to manipulate the genome and epigenome for applications in medicine, biotechnology, and fundamental research.

     

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  • Epigenetic Reprogramming of Cell Types

    Black et al., Cell Stem Cell 2016

    We are using genome engineering tools to reprogram cell lineage specification and direct the differentiation of pluripotent stem cells to model human disease and develop systems to discover novel drug targets.

     

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  • Duke University

    Durham, North Carolina USA

    The size and location of Duke's campus, with physically overlapping Schools of Engineering, Arts & Sciences, and Medicine and proximity to Research Triangle Park, is unique in its capacity to foster interdisciplinary collaboration and promote innovation in biotechnology.

     

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  • Gene Editing to Treat Inherited Disease

    Nelson et. al., Science 2016

    We are using genome editing to correct the mutations that cause inherited disease, thereby treating the underlying cause of the disorder rather than only addressing the symptoms.

     

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  • epigenome editing

    Mapping the Dark Matter of the Genome

    Klann et al., Nature Biotechnology 2017

    We are using genome and epigenome editing tools to annotate the non-coding genome - previously referred to as the "junk DNA" - to understand fundamental principles of gene regulation and discover the mechanisms that determine the genetic component of common, complex disorders.

  • Fitzpatrick Center for Interdisciplinary Engineering, Medicine and Applied Sciences

    The FCIEMAS Building, where the Gersbach Lab is located, is at the heart of Duke's campus and is the physical and intellectual intersection of engineering, science, and medicine.

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Welcome to the Gersbach Lab!

The Gersbach Lab is dedicated to applying innovative methods in molecular and genetic engineering to regenerative medicine, treating genetic disease, and enhancing our understanding of fundamental biological processes. In particular, our research aims to develop new technologies to modify genome sequences, epigenomic regulation, and cellular gene networks in a precise and targeted manner. These new technologies are then applied to correction of genetic diseases, directing cell differentiation, tissue regeneration, drug target discovery, or answering fundamental biological questions regarding gene regulation and genome structure and function. Examples of technologies used in our research include genome and epigenome editing with CRISPR/Cas9 and other DNA-targeting systems, protein engineering, directed evolution, genetic reprogramming, and optogenetics.